Description
Product Characteristics:
Aliases: 2700018B22Rik antibody, AI747285 antibody, DKFZp451O223 antibody, si:dz182n13.3 antibody, slow skeletal muscle antibody, slow-twitch isoform antibody, SSTNI antibody, TNN1 antibody, Tnni1 antibody, TNNI1_HUMAN antibody, Troponin I antibody, Troponin I slow skeletal muscle antibody, Troponin I slow twitch isoform antibody, troponin I type 1 (skeletal, slow) antibody, Troponin I, slow isoform antibody
Target Information: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit\, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]